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Nature Nanotechnology paper on dynamic peptide libraries published

October 2016

In this paper, published in Nature Nanotechnology, we demonstrate methodology to autonomously identify supramolecular polymers based on peptides. By allowing peptides to continuously reorganize their sequences, they will eventually form those polymers that are most suited to the environment at the expense of less favored structures. This methodology- dynamic peptide libraries, or DPL- is inspired by the principles of evolution, and allowed us to identify a range of heretofore unseen peptide-based materials with potential applications in drug delivery and cosmetics.

September 2016

In collaboration with the Tuttle group and recently published in Soft Matter, Ivan has combined computational and experimental methodologies to gain understanding on hierarchical self-assembly of Fmoc-dipeptides showing the lateral aggregation of fibers to form twisted ribbons and elucidating the interactions involved on this process. This study shows how MD simulations combined with spectroscopic and microscopy results enable development of atomistic models which then can be used to gain understanding of Fmoc-dipeptides nano structures.

August 2016

In this recent paper in new Cell Press journal Chem, which was the result of close collaboration with Matt Dalby, University of Glasgow, we describe the development of gels with tunable properties that mimic the nanofibrous structure and mechanical properties of biological tissue. These gels can be used to monitor stem cell differentiation and allow for the identification of molecules involved in differentiation.

June 2016

In Jugal's latest paper latest paper published in ACS Nano, in collaboration with Prof. Matthew J. Dalby's research group in University of Glasgow, we have used emerging rules of managing cell adhesion to prolong mesenchymal stem cell cultures by fabricating controllable nanoscale cell interfaces using immobilised peptides on a 2D surface, that may be enzymatically triggered to change their function. The surfaces can be altered at will to tip adhesion/cytoskeletal balance and initiate differentiation, hence better informing biological mechanisms of stem cell growth. This development of technology that is able to dynamically navigate small differences in cell adhesion is critical in the race to provide regenerative strategies using stem cells.

May 2016

Daniela's latest paper in Biomaterials, in collaboration with the Beatson Cancer Research Institute (UK) shows peptide nanoparticles that change their shape when exposed to endogenous enzymes which are overexpressed in cancer. The morphology transition from spherical nano carrier to immobile nano fibers at the tumor site allows for localized delivery of anticancer drugs, which halts tumor growth. Thus, a pathological hallmark of metastasis (enzyme overexpression) can be exploited to guide therapeutic targeting, tuning a negative prognostic indicator into a therapeutic response.

February 2016

Front cover image of our recently discovered tripeptide emulsifiers. In this paper, we describe a new way to create emulsions with tunable properties, based on very simple biological molecules, as published in the journal Advanced Materials. In collaboration with Tell Tuttle's lab, we used a combination of experiments and simulations to show that dramatically variable oil-in-water emulsions may be produced from tripeptides.

February 2016

In Ivan's latest paper latest paper, collaborating with the Tuttle group, published in ACS Nano we demonstrate that gels based in low molecular weight gelators (LWMG) can be at thermodynamic equilibrium, and hence, that not all of them are metastable. This study introduces a simple packing model which demonstrates that the amphiphilc nature of LMWGs is key to allow fiber networks to be more stable than crystals. This conclusion has critical implications for the theoretical treatment of gels.

February 2016

Inês' latest paper shows on-demand formation of stable emulsions achieved by enzymatic activation. This is achieved using phosphate ester hydrolysis to trigger self-assembly, by conversion of a surfactant-type emulsion to a more permanent emulsion which is stabilized by a nanofibrous network at the oil-in-water droplet surface. The system is characterized using a combination of experimental and computational techniques.

December 2015

In Gary's latest paper in collaboration with the Tuttle group we show a series of tripeptides that form emulsions with sequence tunable properties. Using a combination of simulations and experiments, it is shown that two types of oil-in-water emulsions may be produced, either forming stable interfacial nanofiber networks with remarkable stability, or more conventional surfactant-like monolayers. We are investigating applications in food, cosmetics and biomedicine.

November 2015

In Yousef' latest paper published in Biomacromolecules, we show biomaterials that can dynamically adapt their structure and function by biocatalytic co-assembly. This is demonstrated by dynamic exchange of charged peptide sequences, to achieve selective amplification in the presence of cationic (chitosan) or anionic (heparin) biomacromolecules. The dynamic adaptive potential was demonstrated by sequential morphology changes depending on the sequence of polysaccharide addition. These results may pave the way to materials able to undergo dynamic morphogenesis.

November 2015

The Ulijn group features in the November edition of Bachem's Peptide Trends newsletter. The article profiles our work on biocatalytic peptides and designer peptide nanostructures.

August 2015

The Ulijn group's ASRC labs are quickly gathering critical mass. With the imaging suite and soft nano labs now up and running we are looking forward to a productive summer. Welcome to the new group members!

July 2015

Congratulations to David Velado on having his first year PhD work recognized by the American Chemical Society through a Certificate in Recognition for his "outstanding contributions to the future of chemistry". Nice job!

June 2015

The Ulijn group's ASRC labs are quickly gathering critical mass. With the imaging suite and soft nano labs now up and running we are looking forward to a productive summer. Welcome to the new group members!

May 2015

In this paper published in Angewandte Chemie International Edition, we demonstrate sequence-dependent kinetic pathway selection in chemically fueled catalytic self-assembly of tripeptides. The systems are catalyzed by a-chymotrypsin and driven by hydrolysis of dipeptide aspartyl-phenylalanine-methyl ester (the sweetener aspartame, DF-OMe) in which the control of the lifetime of the nanostructures is dictated by chemical design. Mimicking the unique features of these systems may open up opportunities to create supramolecular systems for non-equilibrium motility and shape control.

December 2014

In this paper we use ultrasound, i.e. high frequency oscillating pressure waves, to achieve transient reorganization of supramolecular peptide nanostructures, which revert back to the original state when sound is switched off. The changes observed were due to an altered balance between H-bonding and π-stacking, giving rise in changes in chiral organisation of peptide building blocks.

October 2014

In this paper, we introduce a new approach to catalyst discovery. This is achieved by combining catalytic self-assembly with phage display. We demonstrate the discovery of catalysts for amide condensation and hydrolysis in water, an extremely challenging reaction with an estimated uncatalyzed half-life in the range of 300 years. While oligopeptides have proven their worth as building blocks for molecular self-assembly and as selective ligands to achieve molecular recognition, our work provides a step towards applying them in design of minimalistic enzyme mimics.

October 2014

Joy's latest paper, published in ACS Nano, demonstrates nanopropulsion of enzyme-quantum dot conjugates by biocatalytic self-assembly. Specifically phosphatase enzymes act as the engine and quantum dots represent the vehicle. When exposed to micellar aggregates (fuel), biocatalytic dephosphorylation results in fibrillar self-assembly of aromatic dipeptide amphiphiles which in turn causes propulsion.

September 2014

After a decade of planning, the ASRC building has been completed. Today, the first researchers of the Nanoscience Initiative, under direction of Dr Rein Ulijn, have moved into the building.

The Nanoscience Initiative will occupy the ground and first floors. Research in Ulijn's group focuses on the development of biomimetic and adaptive nanoscale systems for biomedical and green energy applications. Over the next year they will be joined by further resident Faculty, affiliated members from across CUNY and a dynamic population of visiting scientists from the New York area and across the globe.

The Nanoscience Initiative aims to establish a world-leading research institute in computational and experimental nanoscience in Manhattan. This will be achieved through consolidating existing excellence in Nanoscience at the CUNY campuses coupled with major investment in new faculty, support staff, infrastructure and equipment. The $350-million Advanced Science Research Center (ASRC) is a nucleus for the nanoscience across The City University of New York, a diverse research community encompassing the five boroughs.

June 2014

In Krisha's latest paper published in Angewandte Chemie International Edition, we demonstrate the fabrication of 1D chiral charge-transfer nanofibers through the biocatalytic self-assembly of naphthalenediimide amino acid/dipeptide conjugate acceptors and dialkoxy/hydroxy naphthalene donors. In the obtained hydrogels, the charge-transfer-induced gel-sol-gel transformation led to major morphological changes. The dynamic nanostructures thus formed may provide opportunities for the development of aqueous adaptive nanotechnology.

Read more here.

March 2014

Rein Ulijn is moving to New York City in September 2014, joining the CUNY Advanced Science Research Center, now nearing completion. He will direct the Nanoscience Initiative which will focus on the development of biomimetic and adaptive nanosystems. Please contact Prof Ulijn for inquiries related to PhD, Postdoctoral and Faculty opportunities.

Read more here.

February 2014

Biogelx and Ulijn group research featured in Chemistry world. Rein and Elley explain the business and technology of cell matched gels that present well-defined chemistry in nanostructured gels. The gels help cell biologists address biological problems.

Read more here.

October 2013

Meghan's research article on the anti-microbial effects of morphologically different peptide nanostructures produced via intracellular biocatalytic self-assembly has been published on the front cover of Biomaterials Science.

Read the article here.

October 2013

Congratulations to Babis on his winning poster entitled 'Directing peptide self-assembly using sound waves', at the 1st Peptide Materials conference in Sorrento, Italy.

September 2013

Rein's 2013 RSC Norman Heatley Award has been profiled in Angewandte Chemie alongside other RSC award winners.

Read more here.

July 2013

In our new Chemical Science paper by Krishna, we report on the discovery of functional (rather than just structural) nanostructures using a dynamic combinatorial library (DCL) approach driven by an enzyme-assisted molecular self-assembly, demonstrating an enhanced self-selection and amplification of effective energy transfer nanostructures from complex mixtures of dipeptide derivatives. This approach enabled us to identify a two-component donor/acceptor hydrogel, which forms within minutes and exhibits efficient energy transfer.

July 2013

Our "science of jelly" outreach movie is now available online. A big thanks to all of the pupils and staff at the participating school and to Martin Laycock for filming and producing the movie.

June 2013

Robert Parker, Elenor Irvine, Rein Ulijn and David Willetts

National Recognition for Biogelx!

Biogelx were among the winners of the first RSC Emerging Technologies Competition held at Burlington House on the 5th of June. The Award was presented to us by Universities and Science Minister David Willetts and RSC CEO Robert Parker.

April 2013

Rein wins 2013 RSC Norman Heatley Award!

The Norman Heatley Award recognises and promotes the importance of inter- and multi-disciplinary research between chemistry and the life sciences. It is named in honour of Norman Heatley who played a key role in the development of penicillin.

Professor Ulijn was awarded the prize in recognition of his pioneering work on the development of molecular materials that mimic aspects of biological systems, but are much simpler. He said: "This is wonderful recognition for my research group's hard work and dedication. This external recognition provides motivation and encouragement to continue our journey to develop new biologically inspired technologies and materials. Our objective is to translate some of these to real-world applications in nanotechnology and biomedicine over the next five years."

December 2012

biogelX Ltd formed!

The formation of biogelX Ltd., the commercial vehicle for Ulijn group gel technology was completed on the 18th of December.

More details on this exciting development will follow in the new year.

December 2012

EU Research Interview published!

Rein was recently interviewed by EU Research to discuss his ERC Starting grant on minimal biomimetic systems. An article based on this interview recently appeared in EU Research.

Find out more at the EU Researcher website or read the full article here.

November 2012

Strathclyde has been named University of the Year!

The University of Strathclyde has been named the UK's University of the Year in the 2012 Times Higher Education Awards. Judges described the University as a "bold, imaginative and innovative institution" and said the University's dedication to working with industry took concrete form in the past year, giving a modern slant to its 18th Century founder's vision of a 'place of useful learning'.

November 2012

Mischa's review article on enzyme-responsive materials has been published and made the front cover of the first issue of the new RSC journal Biomaterials Science!

Read more at the Biomaterials Science blog or see all the Ulijn group covers in the gallery on our publications page

November 2012

Members of the Ulijn group attended the Nanopeptide 2012 - Peptides as Nanomaterials & Biomaterials conference, held at the University of Manchester from the 12th to the 14th of November. The event, organised by Stephen Hoare, covered a wide range of topics involving peptide nanomaterials including, 'Peptide Design', 'Dynamic peptide systems and Self assembly' and 'Peptide/Polymer interactions'.

Click here for more information and photos.

July 2012

On the 5th and 6th July the 5th Annual Ulijn Group 'Mega-Meeting' took place. Talks were given by each of the group members on a diverse range of topics from hydrogels for biomedical and green energy applications to the new catalytic peptides.

July 2012

Collaborative team is gelling well! A recent article reporting work from a three way collaboration between the groups of Neil Hunt, Rein Ulijn and Chris Pickett has been chosen as a Hot Article by the referees of the journal Dalton Transactions. The work reports the ultrafast dynamics of a model compound of the active site of the hydrogenase enzyme encapsulated within a peptide-based hydrogel. Such novel encapsulation confers not only significantly improved stability to the compound but also modified dynamical behaviour. Hydrogenase models are bio-inspired synthetic systems capable of catalysing the production of hydrogen and are seen as a new route to hydrogen fuel cell design. Read more here.

June 2012

Rein and Elley, together with collaborators Marie Boyd and Annette Sorensen won the 2012 Dragon's Den Event, part of Glasgow Science Week. The £20K award will be used to investigate the use of biomolecular gels to expand cancer stem cells.

May 2012

Another Marie Curie International Training Network grant on Supramolecular Gels has been awarded during which the Ulijn laboratory will be working with collaborators across Europe.

Two three year PhD research positions will be available from October 2012.

May 2012

The Ulijn group was awarded a new BBSRC grant to study Protein Stabilising Molecular Gels for Biosensing and Bioenergy Devices in collaboration with Prof Richard Cogdell, FRS (University of Glasgow) and Dr Neil Hunt (Physics).

April 2012

The Ulijn group enjoyed delicious food at the 3rd edition of the now traditional International Buffet. The venue was Prof. Ulijn's flat where the group was warmly welcomed. Once a year the group performs a large scale experiment and transforms the kitchen into a culinary laboratory where each member tries their skills at cooking.

Read more here.

March 2012

This March the Ulijn group enjoyed a whisky experience in the Auchentoshan distillery; the only distillery in Scotland to use triple distilling to produce their whisky. What better way to enjoy a relaxing afternoon together and get familiar with Scotland's culture then experience a distillery tour in the country of whisky?

Read more here.

January 2012

An International Training Network grant on Systems Chemistry has started during which the Ulijn laboratory will be working with collaborators across Europe.

Read more at the new website just launched here.

December 2011

The Ulijn group has been awarded a Bridging The Gaps (BTG) grant awarded for pilot study on the construction of reconfigurable soft matter for selective ion binding in collaboration with Neil Hunt, Maxim Federov and Charles Knapp.

December 2011

The Ulijn group has been awarded a £28K feasibility grant from the Korean Institute for Advancement of Technology award to facilitate new collaboration with Korean companies.

November 2011

Strathclyde University has approved the formation of BioGells, a start-up company which will aim to commercialise peptide gels for in vitro cell culture applications.

October 2011

Rein was awarded a $452k grant from US Air Force from the US Air Force Office of Scientific Research to investigate the electronic properties of self assembling peptide nanostructures.

September 2011

Meghan's paper on two-dimensional peptide nanostructures published in Soft Matter!

For more information about these nano-sheets access the full paper here.

March 2011

Congratulations to Lynsey who recently won two poster prizes at the 12th annual meeting of the Surface Science and Biologically Important Interfaces (SSBII) meeting held in Belfast and at the 6th annual meeting of the RSC Biomaterials Chemistry group held at Warwick University in January.

You can see Lynsey in front of her poster here.

February 2011

Polymer Chemistry have identified a new paper from the Ulijn group as a Hot Article. The article describe a collaboration with the Univesity of Montreal to create polymer bioconjugates that are both thermally and enzymatically responsive. This article will feature in a forthcoming Emerging Investigators themed issue of Polymer Chemistry and is mentioned on their blog here.

October 2010

In a new Nature Chemistry paper, we show how we have been able to control the structural organization of self-assembling building blocks by enzymatic catalysis. A range of structures, representing local minima in the free energy landscape, could be accessed from a single precursor building block. Although it seems counter-intuitive, gels that assembled faster showed fewer defects.

September 2010

Rein has been awarded, with Brian Saunders from the University of Manchester, a £250K research grant from the EPSRC. The grant will fund two PhD students and will focus on the development of phosphatase responsive microgel systems for biomedical applications.

August 2010

Rein and Dek Woolfson are the co-editors of a new themed issue of Chemical Society Reviews: Peptide and protein based materials in 2010: from design and structure to function and application. This issue is packed with contributions from the leading laboratories in this exciting field.

August 2010

Rein Ulijn has been awarded a 1.5M Euro starting grant from the European Research Council. The grant will fund three postdoctoral researchers and will investigate "biocatalytic self-assembly" and its applications in biomedical and energy technologies.

July 2010

Lynsey's poster presentation was picked out as a highlight of the Challenges in Physical Chemistry and Nanoscience conference in Hungary by RSC blogger Philip Broadwith. He was impressed with her colorimetric elastase assay. Read more here.

March 2010

A new paper by Jan and Rein shows an enzyme-driven dynamic supramolecular peptide system which displays multiple reversible pathways. This system gives rise to emergent properties that are dictated by environmental conditions and that can be locked in a gel-state. Read more here.

March 2009

A new Ulijn group paper has been published in Small describing a method for controlling the solubility of carbon nanotubes by enzymes. Read more about this new use for Fmoc dipeptides here. The account is illustrated by an inside cover as seen here.

March 2009

A new Soft Matter paper has been published reporting on improved protease sensitive beads for enchanced response under physiological conditions. You can read the paper itself here, and Chemical Biology's comment here.

January 2009

Nature Nanotechnology paper published. You can find our paper on enzyme-catalysed reactions driving self-assembly here and a News & Views article by Sijbren Otto discussing the work here.

[Paper] [News & Views]

September 2008

Rein Ulijn appointed to new WestCHEM chair based at the University of Strathclyde in Glasgow.

July 2008

PSV Reindhoven triumph again in the MIB Football tournament! A reinforced Team Ulijn triumphed again despite Rein being sidelined by injury.

January 2008

Rein Ulijn wins Macro Group UK Young Researchers Medal, to be presented at the Frontiers of Research and Young Researchers Meeting at Warwick University in April 2008.
[http://www2.warwick.ac.uk/fac/sci/chemistry/cim/research/dove/conferences/frontiers-yrm_flier.pdf]

September 2007

Read Rein Ulijn's Blog interview at Nature.com
[http://blogs.nature.com/thescepticalchymist/2007/09/reactions_rein_ulijn_1.html]

August 2007

Team Ulijn Triumph in inaugural MIB football tournament!

April 2007

Rein Ulijn receives Leverhulme Trust Research Leadership Award.
[http://www.mib.ac.uk/news.aspx]

February 2007

Rein Ulijn talks to Soft Matter about his latest paper "Enzyme-triggered cell
attachment to hydrogel surfaces":
[http://www.rsc.org/Publishing/Journals/sm/News/hot_ulijn.asp]

June 2006

Hydrogels research highlighted in Chemistry & Industry:
[http://www.chemind.org/CI/articles.jsp]

May 2006

Dr Ulijn’s research highlighted in Materials Today:
[http://www.materialstoday.com/pdfs/may_2006/research_news.pdf]

Enzyme-Responsive Materials research highlighted in Chemical Science:
[http://www.rsc.org/Publishing/ChemScience/Volume/2006/06/smart_materials.asp] 

March 2006

Dr Ulijn interviewed by regenerationnet.com, the network for regenerative biology:
[http://www.regenerationnet.com/files/Rein.pdf]

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